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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5e4263c3daa93a03c319b59bb91e9d420527428697231b4ef0752ff0993589f2' 
  AND token = 'CRW9aWR5SYVgZ6zfPV+eBtwIjHeblG+178zZ0uiWeSs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}