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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '543a006ab542659c9257261a1e8ac61f0251de28ac9c542b5be0c7efb7e6db24' 
  AND token = 'w1IQ2ivio3GXGVw/qTEKkl/O577rqBtma6Km2jfCl70=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}