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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e8f72f294ff886e752e66d9d1f0ba9a1db3f813d0649ff82b305be644a10e561' 
  AND token = 'yVKbqOnG0H8zTM14X67RgBIS6kLNxXhGmGTsPgglgE0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}