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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '181f6dcfb1956e3c853f9a84578da09afa09f3afdd9770d2f0cf504ccc89f0fd' 
  AND token = 'q31QW3FVUQLf+l91Sm0hgUBUBpDaeRJV0oSS3Z4nRBg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}