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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af99249db982e2539540a7e101846659b6a849901df43e274601ec2649ae46c9' 
  AND token = 'jtIqWMMp/xs2MLSOEDCrqJ+/f8JxZszNrd0VsFVc4cI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}