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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2ea05d53deb97a3610b57d1055fca607292ec1b56905d7463736c724a212c700' 
  AND token = 'lSYkmAg4NA3zpfQ2aNRW6UDuRlq1FzVJlOdhZAMOVI0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}