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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '65fafad2fa4988f00a75997f8e436f4fd662130bf158c0f18c92a3038988b8a6' 
  AND token = 'avSDHsnxr/1agFPNlAS6lK/jeq++zcLN4utCXCmEZQ8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}