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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5f49b7fc7565162114660d0666995ecaac99ab93e5b8d22b3a30a02d5c854156' 
  AND token = 'D48ZNSUF1VXBf6GMwmDbqaFoTauS3oo+j1YcZF/ArBE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}