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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b5f75c5af7a2fe02828686f83da4156b2eb8dbbf57e63878d08edde7d21ce155' 
  AND token = 'Eb55N05iGlaLYJWpnUYbhg/ezRvTqxMg4vo9vT0t7oo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}