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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed7b3297c036af6cb93d53da1cd37feb738e0fd8c17d2f66607783e569c50545' 
  AND token = '50/l1vRqeEujWAd6RGAYQ47jh+jfQPxJdVFubUEL1xs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}