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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3b370254c3301042e4707c96710ca067177086978696584df9e428e3f99be9d2' 
  AND token = 'Ysn9zp+RiaqyU1x5IGGCZC8hbFuB27+U0p3DzYWqSAI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}