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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45e22096dd27e862d81c88a41d92ad87f1472b06835229bde2bb78ee9f127d78' 
  AND token = '3llRWMG2DILkFtEG5e33+eXz8XP0Grm1jWcW9XiejyA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}