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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78b22ea38831ee9a8b462abc1632fe474822a4fe6580528f820b67693315a1c4' 
  AND token = 'NTdwq/rKst1JL8QAaAMEldWMAEuu4iZOwhY+iZ0wJQc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}