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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f81461394e0bc8e0257a7c7c92612fdfa62f706971653e4613ac7feb68c3e0cb' 
  AND token = 'gWQ9BDUz9psCDaFoXfgSD0yXt9f3F5eV3r+HKvFo53I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}