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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e67c8b65b344bd64b487dcffdfb10011ca1a90f58eb6f1712fd57edcd198b3c9' 
  AND token = '6U1j00kgAweBR9tNN6uJCRUE5pd7wnPLEIt+n1Uji6g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}