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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a8ff15735ab82410036706125799af441d7af30c87a17a02dbf062984a1a9654' 
  AND token = 'GXCCm27B18gEDlEpy5MEk8fj+/TtE3fasQsjN5H53Kc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}