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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd1235ff75bf3be21fda019e8aaf550aebe38aa7f2f01571975f92e23e835c560' 
  AND token = 'ewdH9fOH+iXxGZqqLR7XXHDp2aqs7GvovzF+yyjEZOA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}