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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f1f157309d583286310148e6d1de6a135f9ce440655e0a92f951f2b679b8d304' 
  AND token = '4+2v8VFE+U5RvLogWqPpkfhRdGeP+xWD/YAEdFEedNc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}