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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '3d3e7885748263a2f33ddc49e504be47e0899c318b267e9a37a20a361343afa8' 
  AND token = 'JIOb0a3eA3//NOfvcUA3tJTkIwqsqTbV7JhnntDTPA4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}