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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '18112a2b80d81d943e7c0a475b967b5767927d0a2baeca98424f10944de6d68d' 
  AND token = 'YpdS21cXJuna/fTU9dUFQoH8rpGEbGnbpWUKmt5vCk4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}