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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a65c9b1b9b9472956e02b250d5a3a2e3b3e45cc42824aaa185ca64bbd6995365' 
  AND token = 'r2WC8ENVvmSirz988bSW/9j6k5B0ULRtRzSjoC7PhOA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}