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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f287d920296ebbe8e8b5ca2ab8a3b8e0dac7c36a8ff77e03c2775304d4896745' 
  AND token = 'py5LrZUydMKQJD6vGVu/6asdJ0d1uNv1hswyE/rkLsc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}