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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '147b5e082b934b9cb8be852bdea1df4aa7da0665ba016396ceeaae1e1d6423e1' 
  AND token = 'k+qQ0R+xp/YJ+HEHxdl6uMTUDkYC+CFNQTVbHUkhnNw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}