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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1aa49b8aa179e10ca791cc5317113ad4b2afef66c89756d28a9fab36e352bf8f' 
  AND token = 'HFSGxiAMqDATlfqbMX/CH4EPPp4n7MPjMQWDyxYagMA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}