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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af453a194e9f7846b4814000898ccdfa538c52cae501f1e054d3c1abab891c8a' 
  AND token = 'QaPJ7LEEnzDAiaxTgj196+MXHJ4UkcOSQWFgnDZhdyA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}