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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '442b588bdb1d01f6bc55206ac81194f278ef3b04edb94f7cfd9d2adfa4f208ed' 
  AND token = 't3Lkjb4QlqZkB4lK6yq1Iajd0q5SwMRAmoWwkT2NRp0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}