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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a44a0f22fa895b66107c0d9181d02e450c8ee02fcc06fd2b11e729c80126ef05' 
  AND token = 'V+6EGJ6qrVXkd0Vt2nFBhofMQGwrFoMNOsLHTksc1ao=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}