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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '461e7f9bd2a94901e9f6dadafee946255c0d85fff574188ce51f505eb9a7f2f4' 
  AND token = '0DJHyrjWCwAVYDxHJI+Z7/D79YVsJzYT+3EdSawGz4I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}