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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8e2236106883cef1c700d0127fe8170a8e78ff0e1fb4f3d60e88e3fc2275f718' 
  AND token = 'r3nuzpMwJHdgVZIs5t28d3G0I26RwaRRR2jfDb8xD88=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}