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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8777edf58e059c9f066099dd4cfdd58a0f50336be757153412955d95597500b1' 
  AND token = 'SguB6KeaQ1eHDeKYvE6X/1UHTesrK21IIVvr/j365wE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}