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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c8648437339b6cf4ce7fbed018f72a5ff8bef972e07ef5a3ba82b64048ff5026' 
  AND token = 'POECOzJpLiYRGMKs6fdibxFjkDnMEASB2b4FZdaXPvU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}