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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e1b0403654192d890bf8ade023e7e231b0b0053725cb118b57b08e405fa65b8d' 
  AND token = 'cRRmN0w5yKlpKfHraismRBgs4fZWKLWwA2MT0kT/YHc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}