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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25cd5035e5680b5f811daf8d0426c525d5087b1e605f771a1129e6a7dc021c58' 
  AND token = 'NPgqUX2Hdd1UXUsy6BPA+JgZG7gyTIKZcKsov139jAY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}