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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80064123b2905c25e4b500641e247de16a4cf692c59d5313c31da5036e0dd8b5' 
  AND token = '2/iQlXrge/XHdlHCqlSC32RLwdAt27JkTXbIG6KMXwI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}