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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2a4fce8e9230d87f89cb28ce891a7cbae12399b1c5beff91bac99b1947d57442' 
  AND token = 'ayGHx3kRVjE2Rwm/mEIgA4I18IqPfMgbQGjNRmGD+aE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}