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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c72aeb41c806aa01c9cea66a6b61dd577d9da3fc709b2959db4870e964280f89' 
  AND token = '8eQp0262r7H5xFie8QnTcyM4g6vs+IxY7LWy0gCVyh8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}