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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '180c7e3b97cefd96f57c6cd1c6b9f797429875a72b04b344f0834f3cd72147cd' 
  AND token = 'msPXQyUuopoxfpzbVNcOYl73Qr8zf8WCXGyW14kfX5s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}