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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'acd5105102f28b930014c463b88d1c83413d1508e8f1298706d313acead61dda' 
  AND token = 'UaygWaMbR+DQgILtAZ0TpqyzbBDQFVeX9kF5d6qY62M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}