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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6e3a406898be70c1d16fa41bb165e0796f10e6dbfd33be4b08fd48bf2bf7a284' 
  AND token = 'IGiPfT9Wz+HDjpsRrcvC9N87m25Q1+bDai8ZV4fUIQM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}