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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '452a861a7580ec78b936d2b41f41e7ea130c31713baaa435ace44f1605806220' 
  AND token = 'T0p2CPVyi0Yfe/+EhRkh7Toml8lc7BeUvsr6sFTFM0I=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}