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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a39d6269f6d63eb1016cb219dd05adfd4e2f6425bc84fed7d8323d00b7492735' 
  AND token = 'tIBJDUTdzXo2vcgN0BclCTH76akQxf0inGfMdz/0XDs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}