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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '444c7a0176c9144e539dd41053dbfb442c28eb38e3335ca2833218e36ebea010' 
  AND token = 'j28FKVsaE9d9+eO1/ICjVrQ1XsodF8QlZ04griKQKCI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}