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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4219045cb607af769f5160568d648c2e43dc2dd5afa8da6216d08be77b4c2a29' 
  AND token = 'jPEODH6+hnrHiNiEH/UGLyO1dZj/x22Utt8m3NJOoKc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}