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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '14e01d59fa9455f236f06d1efb6eb93e2248675751a40a61c9b0fc2a79e60d2a' 
  AND token = '1SGSWKOuJ6BvSF1Hpsju4M7VbDbS1DURSa8OiMEGhuE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}