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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '80a6ab9b7d1f9b08b555e79a9569e80257c241228dc2d48ce788c1d5aaf5a16e' 
  AND token = 'qmwqWWLtzVMhOgLzAa7MemHEQ/Xw3b3sKot3ZfmcngM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}