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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ad7a12eb511ceff49f2e28d12578c921f46de0741308ff1db04e8743b418a8ec' 
  AND token = 'KwretkT6JOsFwaR9hmKL0cYmeytvLalMMdmvI+W0Hoc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}