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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f701ed7fd80f6624200da87a06517ad59e94cbb3ded10debaa39534fd6e4d13a' 
  AND token = '4b0bEADqOK0zjy1E5qUFmVuR6xGb6aLSCnA1xHVm3s4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}