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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '27b2e1a869cd7595bc070ea65f6adcfed435c51bf96dc65bda6ef9d10c857916' 
  AND token = 'WMdm96fH5mRS88l5noEqNLfT0KHsdk6xUZ7E4gf1Qnw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}