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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b453ef6f7c0649b252a73cba097c5bed7d708077f0b957bb0255875a3a304aff' 
  AND token = 'k5dlZYWBDmKzxcSQKdvvKOcWrV9fJRCbnPvps7Z+0pE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}