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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7b5e46765ff393c95a16ec7da78bfc6357e68fc824a211b6bcfa87a1fb35ab18' 
  AND token = 'dIs/uDoxPOoWon5umafUDQ6KX0Y+MaXG1t2jV8xaLT0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00055

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}